Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells

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• 作者：Dan Cao ; Xinhua Song ; Li Che ; Xiaolei Li ; Maria G. Pilo ; Gianpaolo Vidili ; Alberto Porcu ; Antonio Solinas ; Antonio Cigliano ; Giovanni M. Pes ; Silvia Ribback ; Frank Dombrowski ; Xin Chen ; Lei Li and Diego F. Calvisi
• 刊名：Liver International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：37
• 期：1
• 页码：80-89
• 全文大小：2497K
• ISSN：1478-3231

文摘

Although it is well established that fatty acids (FA) are indispensable for the proliferation and survival of cancer cells in hepatocellular carcinoma (HCC), inhibition of Fatty Acid Synthase (FASN) cannot completely repress HCC cell growth in culture. Thus, we hypothesized that uptake of exogenous FA by cancer cells might play an important role in the development and progression of HCC. Lipoprotein lipase (LPL) is the enzyme that catalyses the hydrolysis of triglycerides into free fatty acids (FFA) and increases the cellular uptake of FA.