Synchronized Chiral Induction between [5]Helicene-Spermine Ligand and B-Z DNA Transition

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• 作者：Kensuke Kawara ; Dr. Genichiro Tsuji ; Prof. Dr. Yosuke Taniguchi and Prof. Dr. Shigeki Sasaki
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：23
• 期：8
• 页码：1763-1769
• 全文大小：1151K
• ISSN：1521-3765

文摘

The 2,13-dimethoxy[5]helicene–spermine ligand 8 b possesses an axial chirality. The racemic 8 b was bound to B-DNA by the accompanying induction of its (P)-chirality together with the B-to-Z helicity change of the duplex DNA, [(dC-dG)₃]₂. The (P)-chirality of the bound 8 b, in turn, transitioned to the (M)-chirality according to the Z-helicity of the DNA. These results illustrate the chirality synchronization between the DNA and the ligand.