Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds

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• 作者：Dr. Yuanchen Dong ; Dr. Yuhe Renee Yang ; Yiyang Zhang ; Dianming Wang ; Dr. Xixi Wei ; Saswata Banerjee ; Dr. Yan Liu ; Dr. Zhongqiang Yang ; Dr. Hao Yan and Dr. Dongsheng Liu
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：February 1, 2017
• 年：2017
• 卷：56
• 期：6
• 页码：1586-1589
• 全文大小：2864K
• ISSN：1521-3773

文摘

We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.