Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy

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• 作者：Dr. Wenpei Fan ; Nan Lu ; Prof. Peng Huang ; Dr. Yi Liu ; Zhen Yang ; Dr. Sheng Wang ; Dr. Guocan Yu ; Dr. Yijing Liu ; Dr. Junkai Hu ; Dr. Qianjun He ; Prof. Junle Qu ; Prof. Tianfu Wang and Prof. Xiaoyuan Chen
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：January 24, 2017
• 年：2017
• 卷：56
• 期：5
• 页码：1229-1233
• 全文大小：2676K
• ISSN：1521-3773

文摘

Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H₂O₂, a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H₂O₂ can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H₂O₂–NO cooperative anticancer effect with minimal adverse effect.