Interband Absorption Enhanced Optical Activity in Discrete Au@Ag Core-Shell Nanocuboids: Probing Extended Helical Conformation of Chemisorbed Cysteine Molecules

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• 作者：Zhi Yong Bao ; Prof. Wei Zhang ; Dr. Yong-Liang Zhang ; Jijun He ; Prof. Jiyan Dai ; Dr. Chi-Tung Yeung ; Dr. Ga-Lai Law and Dr. Dang Yuan Lei
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：January 24, 2017
• 年：2017
• 卷：56
• 期：5
• 页码：1283-1288
• 全文大小：3009K
• ISSN：1521-3773

文摘

Detailed understanding of the interaction between a chiral molecule and a noble metal surface is essential to rationalize and advance interfacial self-assembly of amino acids and metal-mediated anchoring of proteins. Here we demonstrate that individual Au@Ag core–shell nanocuboids can serve as a plasmonic reporter of an extended helical network formed among chemisorbed cysteine molecules, through generating an interband absorption enhanced, Ag-surface-exclusive circular dichroism (CD) band in the UV region. The observed unusual, strong CD response in the hybrid Au@Ag–cysteine system can be used to probe in real time conformational evolution and structural rearrangement of biomolecules in general and also monitor the interfacial interaction between a metal surface and an adsorbed molecule, opening up the possibility of using Ag nanostructures as promising stereochemically attuned nanosensors.