Photo-Modulated Therapeutic Protein Release from a Hydrogel Depot Using Visible Light

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• 作者：Dr. Johan S. Basuki ; Dr. Fengxiang Qie ; Dr. Xavier Mulet ; Dr. Randy Suryadinata ; Aditya V. Vashi ; Yong Y. Peng ; Dr. Lingli Li ; Dr. Xiaojuan Hao ; Prof. Dr. Tianwei Tan and Dr. Timothy C. Hughes
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：January 19, 2017
• 年：2017
• 卷：56
• 期：4
• 页码：966-971
• 全文大小：4375K
• ISSN：1521-3773

文摘

The use of biomacromolecular therapeutics has revolutionized disease treatment, but frequent injections are required owing to their short half-life in vivo. Thus there is a need for a drug delivery system that acts as a reservoir and releases the drug remotely “on demand”. Here we demonstrate a simple light-triggered local drug delivery system through photo-thermal interactions of polymer-coated gold nanoparticles (AuNPs) inside an agarose hydrogel as therapeutic depot. Localized temperature increase induced by the visible light exposure caused reversible softening of the hydrogel matrix to release the pre-loaded therapeutics. The release profile can be adjusted by AuNPs and agarose concentrations, light intensity and exposure time. Importantly, the biological activity of the released bevacizumab was highly retained. In this study we demonstrate the potential application of this facile AuNPs/hydrogel system for ocular therapeutics delivery through its versatility to release multiple biologics, compatibility to ocular cells and spatiotemporal control using visible light.