Chloroacetate Promotes and Participates in the Oxidative Annulation of Pyridines/Isoquinoline by Using Oxygen as the Oxidant

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• 作者：Dr. Yuanyuan Yue ; Yangyang Sun ; Shufang Zhao ; Xuyang Yan ; Rong Li ; Yaru Shi ; Dr. Kelei Zhuo and Dr. Jianming Liu
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：December 6, 2016
• 年：2016
• 卷：11
• 期：23
• 页码：3339-3344
• 全文大小：1451K
• ISSN：1861-471X

文摘

The aerobic oxidative annulation of chalcones, pyridines/isoquinoline and ethyl chloroacetate to indolizines was achieved by cascade reaction. Various functional groups on chalcones were tolerated. And different pyridines derivatives could also be suitable substrates. Ethyl chloroacetate is an essential component in participating of the oxidative annulation process. Overall, this protocol is very practical and efficient by using molecular oxygen as oxidant with high selectivity for the annulation product.