Triterpenoid Saponins with Potential Cytotoxic Activities from the Root Bark of Ilex rotunda Thunb.

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• 作者：Wei-Jie Liu ; Yu-Yuan Peng ; Hao Chen ; Xian-Fang Liu ; Jing-Yu Liang and Jian-Bo Sun
• 刊名：Chemistry & Biodiversity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：14
• 期：2
• 全文大小：240K
• ISSN：1612-1880

文摘

A new 19-oxo-18,19-seco-ursane-type triterpeonoid saponin, laevigin E (8), together with 17 known compounds (1 – 7 and 9 – 18) were isolated from the root bark of Ilex rotunda Thunb. Their structures were determined by various spectroscopic analysis. Among them, compounds 6, 9, 11, and 18 were isolated from this species for the first time, while compounds 10 and 12 were firstly isolated from the family Aquifoliaceae. Biological activity assay showed that all triterpenoids exhibit moderate cytotoxic activities against MCF7, A549, HeLa and LN229 cell lines. The four triterpenoid saponins (3, 4, 6, and 8) exhibit slightly better activities compared to the four triterpenoid sapogenins (1, 2, 5, and 7). Compound 8 showed the best cytotoxicity against A549, HeLa and LN229 cell lines with IC₅₀ of 17.83, 22.58 and 30.98 μm, respectively.