Cytotoxic and Anti-inflammatory Sesquiterpenes from Ainsliaea henryi

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• 作者：Ren-Tao Zeng ; Xue-Yun Dong ; Xing Fang ; Niao Yang ; Zhi-Ran Shi ; Zhi-Guo Zhuo ; Yun-Heng Shen and Wei-Dong Zhang
• 刊名：Chemistry & Biodiversity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：14
• 期：2
• 全文大小：267K
• ISSN：1612-1880

文摘

Three new sesquiterpenoids, 4α-hydroxyeudesm-11(13)-en-12-yl 3-methylbutanoate (1), diaspanolide E (2), and (13α)-germacra-1(10),4-dien-12,8α-olid-15-oic acid (3), along with eight known sesquiterpenoids (4 – 11), were isolated from the aerial parts of Ainsliaea henryi. The chemical structures of compounds 1 – 3 were elucidated by spectroscopic analysis (1D-, 2D-NMR, MS and HR/MS). All isolates were evaluated for their inhibitory activities against nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophage cells. Compound 10 exhibited significantly inhibition against NO release with an IC₅₀ value of 6.54 ± 0.16 μm. Also, all isolated compounds were tested for cytotoxicity against three human tumor cell lines A549, MGC803, and HCT116, among which compound 5 significantly inhibited the proliferation of MGC803 cell lines with an IC₅₀ value of 2.2 ± 0.2 μm.