Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells

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• 作者：Joon Young Bae ; Jin Woo Lee ; Qinghao Jin ; Hari Jang ; Dongho Lee ; Youngsoo Kim ; Jin Tae Hong ; Mi Kyeong Lee ; Moon Soon Lee and Bang Yeon Hwang
• 刊名：Chemistry & Biodiversity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：14
• 期：2
• 全文大小：198K
• ISSN：1612-1880

文摘

Bioassay-guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C-methylated flavan-3-ols, bletillanols A (1) and B (2), along with ten known compounds (3 – 12). Their structures were determined by using extensive spectroscopic analysis including 1D-, 2D-NMR, and circular dichroism data. All of the isolated compounds were tested for their inhibitory potential on the nitric oxide generation in LPS-stimulated RAW 264.7 cells.