Long-Term Real-Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer

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• 作者：Sing Shy Liow ; Qingqing Dou ; Dan Kai ; Zibiao Li ; Sigit Sugiarto ; Chris Yee Yung Yu ; Ryan Tsz Kin Kwok ; Xiaohong Chen ; Yun-Long Wu ; Seow Theng Ong ; Atish Kizhakeyil ; Navin K. Verma ; Ben Zhong Tang and Xian Jun Loh
• 刊名：Small
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：13
• 期：7
• 全文大小：1819K
• ISSN：1613-6829

文摘

A new drug concentration meter is developed. In vivo drug release can be monitored precisely via a self-indicating drug delivery system consisting of a new aggregation-induced emission thermoresponsive hydrogel. By taking the advantage of a self-indicating system, one can easily detect the depletion of drugs, and reinject to maintain a dosage in the optimal therapeutic window.