Pancreatic Cancer: Targeted Co-delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer (Small 2/2017)

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• 作者：Yang Li ; Hebin Wang ; Kai Wang ; Qinglian Hu ; Qi Yao ; Youqing Shen ; Guocan Yu and Guping Tang
• 刊名：Small
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：13
• 期：2
• 全文大小：2415K
• ISSN：1613-6829

文摘

A new type of tumor-targeted nanovehicle (PSPGP) is successfully synthesized for co-delivery of PTX (paclitaxel) and TR3 siRNA, by G. Yu, G. Tang, and co-workers in article number 1602697. In vitro and in vivo investigations demonstrate that the redox-responsive PSPGP exhibited enhanced endosomal escape and intracellular degradation, which facilitates PTX and TR3 siRNA release, effectively improving the anti-tumor efficacy.