Peptoids: Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization (Small 1/2017)

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• 作者：Zijian Zhao ; Ling Zhu ; Haiyun Li ; Peng Cheng ; Jiaxi Peng ; Yudan Yin ; Yang Yang ; Chen Wang ; Zhiyuan Hu and Yanlian Yang
• 刊名：Small
• 出版年：2017
• 出版时间：January 4, 2017
• 年：2017
• 卷：13
• 期：1
• 全文大小：6790K
• ISSN：1613-6829

文摘

Antiamyloidogenic agents have promising application potential in AD therapies. In article number 1602857, L. Zhu, Z. Hu, Y. Yang, and co-workers present an Aβ42-binding agent amyloid inhibitory 1 (AIP1), demonstrate its inhibitory effect on Aβ42 oligomerization and fibrillation, and show that AIP1 rescue Aβ42-induced cytotoxicity through decreasing Aβ42 oligomer content is related to cell membrane permeability.