Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides

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• 作者：Weicang Wang ; Jun Yang ; Weipeng Qi ; Haixia Yang ; Chang Wang ; Bowen Tan ; Bruce D. Hammock ; Yeonhwa Park ; Daeyoung Kim and Guodong Zhang
• 刊名：Obesity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：132-140
• 全文大小：881K
• ISSN：1930-739X

文摘

Enzymatic metabolism of polyunsaturated fatty acids leads to formation of bioactive lipid metabolites (LMs). Previous studies have shown that obesity leads to deregulation of LMs in adipose tissues. However, most previous studies have focused on a single or limited number of LMs, and few systematical analyses have been carried out.