Frequent PIK3CA activating mutations in nipple adenomas

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• 作者：Jau-Yu Liau ; Yi-Hsuan Lee ; Jia-Huei Tsai ; Chang-Tsu Yuan ; Chia-Yu Chu ; Jin-Bon Hong and Yi-Shuan Sheen
• 刊名：Histopathology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：70
• 期：2
• 页码：195-202
• 全文大小：1013K
• ISSN：1365-2559

文摘

Nipple adenoma (NA) is a rare benign epithelial tumour occurring in the nipple. Histologically, it exhibits variable and often mixed adenosis-like and usual ductal hyperplasia-like growth patterns. Morphologically, it is similar to other benign proliferative breast lesions occurring in the breast parenchyma, which have been shown to harbour activating mutations in PIK3CA, AKT1 or, less frequently, in RAS in more than 50% of cases. In this study, we aimed to analyse the mutation status of PIK3CA, AKT1, RAS and BRAF in NAs and correlated the mutation status with the histological features.