Structural elucidation of koumine metabolites by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

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• 作者：Sa Xiao ; Ya-Jun Huang ; Zhi-Liang Sun and Zhao-Ying Liu
• 刊名：Rapid Communications in Mass Spectrometry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：31
• 期：3
• 页码：309-314
• 全文大小：821K
• ISSN：1097-0231

文摘

Koumine is one of the major components of total alkaloids from Gelsemium. Koumine possesses a variety of interesting pharmacological effects, including anti-tumor, anti-inflammatory, and anxiolytic activities. It might be a promising lead drug because of its pharmacological activities and mild toxicity. However, little information is available on the metabolism of koumine.