Nanoscale Fluorescent Metal-Organic Framework@Microporous Organic Polymer Composites for Enhanced Intracellular Uptake and Bioimaging

详细信息    查看全文

• 作者：Dr. Lei Wang ; Dr. Weiqi Wang ; Dr. Xiaohua Zheng ; Dr. Zhensheng Li and Prof. Zhigang Xie
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 26, 2017
• 年：2017
• 卷：23
• 期：6
• 页码：1379-1385
• 全文大小：5769K
• ISSN：1521-3765

文摘

Polymer-modified metal–organic frameworks combine the advantages of both soft polymers and crystalline metal–organic frameworks (MOFs). It is a big challenge to develop simple methods for surface modification of MOFs. In this work, MOF@microporous organic polymer (MOP) hybrid nanoparticles (UNP) have been synthesized by epitaxial growth of luminescent boron-dipyrromethene (BODIPYs)–imine MOPs on the surface of UiO-MOF seeds, which exhibit low cytotoxicity, smaller size distribution, well-retained pore integrity, and available functional sites. After folic acid grafting, the enhanced intracellular uptake and bioimaging was validated.