Pathophysiology of peripheral arterial disease in diabetes mellitus

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• 作者：Shao-ling Yang ; Lv-yun Zhu ; Rui Han ; Lei-lei Sun ; Jun-xia Li and Jing-tao Dou
• 刊名：Journal of Diabetes
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：9
• 期：2
• 页码：133-140
• 全文大小：2898K
• ISSN：1753-0407

文摘

Peripheral arterial disease (PAD) increases the risk of lower extremity amputation. It is also an independent predictor of cardiovascular and cerebrovascular ischemic events, affecting both the quality and expectancy of life. Many studies have demonstrated that the prevalence of PAD in patients with diabetes mellitus (DM) is higher than in non-diabetic patients. In diabetic patients, PAD occurs early with rapid progression, and is frequently asymptomatic. Multiple metabolic aberrations in DM, such as advanced glycation end-products, low-density lipoprotein cholesterol, and abnormal oxidative stress, have been shown to worsen PAD. However, the role of DM in PAD is not completely understood. The purpose of the present article is to review and discuss the pathophysiology of PAD in DM.