Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines

详细信息    查看全文

• 作者：Longin Justin Clair Bonazaba Milandou ; Dr. Hé ; lè ; ne Carreyre ; Dr. Sé ; bastien Alazet ; Gino Greco ; Dr. Agnè ; s Martin-Mingot ; Dr. Cé ; lestine Nkounkou Loumpangou ; Prof. Jean-Maurille Ouamba ; Dr. Fodil Bouazza ; Dr. Thierry Billard and Dr. Sé ; bastien Thibaudeau
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：January 2, 2017
• 年：2017
• 卷：56
• 期：1
• 页码：169-172
• 全文大小：1232K
• ISSN：1521-3773

文摘

Upon activation under superacid conditions, functionalized tailor-made N-SCF₃ sulfenamides served as reagents for the trifluoromethylthiolation of aromatic amines. This method has a broad substrate scope and can be used for the late-stage functionalization of complex molecules such as alkaloids or steroids. Mechanistic studies based on in situ low-temperature NMR spectroscopy revealed the involvement of dicationic superelectrophilic intermediates.