Preparation of five 3-MCPD fatty acid esters, and the effects of their chemical structures on acute oral toxicity in Swiss mice

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• 作者：Man Liu ; Jie Liu ; Yizhen Wu ; Boyan Gao ; Pingping Wu ; Haiming Shi ; Xiangjun Sun ; Haiqiu Huang ; Thomas TY Wang and Liangli(Lucy) Yu
• 刊名：Journal of the Science of Food and Agriculture
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：97
• 期：3
• 页码：841-848
• 全文大小：896K
• ISSN：1097-0010

文摘

3-monochloro-1, 2-propanediol fatty acid esters (3-MCPDEs) comprise a group of food toxicants formed during food processing. 3-MCPDEs have received increasing attention concerning their potential negative effects on human health. However, reports on the toxicity of 3-MCPD esters are still limited. To determine the effects of fatty acid substitutions on the toxicity of their esters, 1-stearic, 1-oleic, 1-linoleic, 1-linoleic-2-palmitic and 1-palmitic-2-linoleic acid esters of 3-MCPD were synthesized and evaluated with respect to their acute oral toxicities in Swiss mice.