Binge Alcohol Intake After Hypergravity Stress Sustainably Decreases AMPK and Transcription Factors Necessary for Hepatocyte Survival

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• 作者：Sang Gil Lee ; Hong Min Wu ; Chan Gyu Lee ; Choong Sik Oh ; So Won Chung and Sang Geon Kim
• 刊名：Alcoholism: Clinical and Experimental Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：41
• 期：1
• 页码：76-86
• 全文大小：617K
• ISSN：1530-0277

文摘

Binge alcohol consumption elicits mitochondrial dysfunction in hepatocytes. An understanding of the effect of ethanol (EtOH) exposure after hypergravity stress on liver function may assist in the implementation of pathophysiological countermeasures for aerospace missions. This study investigated whether a combination of hypergravity stress and binge alcohol intake has a detrimental effect on AMP-activated protein kinase (AMPK) and other molecules necessary for hepatocyte survival.