Synthesis of Novel Quinoline-substituted 1,4-dihydropyridine Derivatives via Hantzsch Reaction in Aqueous Medium: Potential Bioactive Compounds

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• 作者：Morteza Shiri ; Atefeh Nejatinezhad-Arani and Zeinab Faghihi
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：131-136
• 全文大小：2274K
• ISSN：1943-5193

文摘

The synthesis of a novel series of substituted 1,4-dihydropyridines was achieved in aqueous media by base-catalyzed three-component Hantzsch reaction of 2-chloroquinoline-3-carbaldehydes, ammonium acetate, and alkyl acteoacetate in good to high yields. Important advantages of this method are easy access to a library of novel quinoline and quinolone derivatives, green reaction conditions with water as solvent, and ease of purification.