3-(3,5-Dimethyl-1H-Pyrazol-1-yl)-3-Oxopropanenitrile as Precursor for Some New Mono-Heterocyclic and Bis-Heterocyclic Compounds

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• 作者：Nadia H. Metwally ; Fathy M. Abdelrazek ; Salwa M. Eldaly and Peter Metz
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：289-294
• 全文大小：781K
• ISSN：1943-5193

文摘

pan class="TH_term3">3-(3,5-Dimethyl-1 H -pyrazol-1-yl)-3-oxopropanenitrilepan> href="#jhet2578-eo-0001" rel="references:#jhet2578-eo-0001"> was used as a cyanoacetylating agent for synthesis of the acetanilide derivative href="#jhet2578-eo-0003" rel="references:#jhet2578-eo-0003">. Compound href="#jhet2578-eo-0003" rel="references:#jhet2578-eo-0003"> was utilized as a key pan class="TH_term4">intermediatepan> for the synthesis of some new mono-chromene and di-chromene derivatives href="#jhet2578-eo-0023" rel="references:#jhet2578-eo-0023"> and href="#jhet2578-eo-0034" rel="references:#jhet2578-eo-0034">, the dihydrazo derivatives href="#jhet2578-eo-0043" rel="references:#jhet2578-eo-0043">, and the dithiazole derivatives href="#jhet2578-eo-0052" rel="references:#jhet2578-eo-0052"> via the condensation with o-hydroxybenzaldehyde derivatives, the coupling with aryl diazonium salts, or the reaction with http://www.wiley.com/namespaces/wiley" xmlns:cr="urn://wiley-online-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2578-eo-2005">pan class="TH_term1 TH_term3">phenyl isothiocyanatepan> in presence of KOH followed by phenacyl bromide derivatives respectively.