Synthesis and Bioactivities of Novel 1-(3-Chloropyridin-2-yl)-N-Substituted-5-(Trifluoromethyl)-Pyrazole Carboxamide Derivatives

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• 作者：Zhibing Wu ; Shixi Wu ; Yiqiang Ye ; Xiang Zhou ; Peiyi Wang ; Wei Xue and Deyu Hu
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：325-330
• 全文大小：960K
• ISSN：1943-5193

文摘

A series of novel 1-(3-chloropyridin-2-yl)-N-substituted-5-(trifluoromethyl)-pyrazole carboxamide derivatives were synthesized and characterized by IR, ¹H NMR, ¹³C NMR, MS, and elemental analysis. All the target compounds were tested in vitro for their antibacterial activities and antifungal activities. The preliminary bioassays indicated that compound exhibited excellent activity against Xanthomonas oryzae (94.9% and 84.9%) at different concentrations (200 µg/mL and 100 µg/mL), which was higher than that of Bismerthiazol (94.6% and 64.0%), respectively. At the same time, most of the compounds exhibited moderate antifungal activities against four kinds of phytopathogenic fungi