Design and Synthesis of Novel 6-(5-Methyl-1H-1,2,3-triazol-4-yl)-5-[(2-(thiazol-2-yl)hydrazono)methyl]imidazo[2,1-b]thiazoles as Antimicrobial Agents

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• 作者：Bakr F. Abdel-Wahab ; Rizk E. Khidre and Ghada E. A. Awad
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：489-494
• 全文大小：425K
• ISSN：1943-5193

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Novel 6-(1,2,3-triazol-4-yl)-5-[(2-(thiazol-2-yl)hydrazono)methyl]imidazo[2,1-m>bm>]thiazoles href="#jhet2610-eo-0015" rel="references:#jhet2610-eo-0015">, href="#jhet2610-eo-0022" rel="references:#jhet2610-eo-0022 #jhet2610-eo-0023 #jhet2610-eo-0024 #jhet2610-eo-0025">, and href="#jhet2610-eo-0027" rel="references:#jhet2610-eo-0027"> were prepared by reaction of thiosemicarbazone href="#jhet2610-eo-0012" rel="references:#jhet2610-eo-0012 #jhet2610-eo-0013"> with either hydrazonoyl chloride href="#jhet2610-eo-0014" rel="references:#jhet2610-eo-0014">, phenacylbromides href="#jhet2610-eo-0016" rel="references:#jhet2610-eo-0016"> or mlns:w="http://www.wiley.com/namespaces/wiley" xmlns:cr="urn://wiley-online-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2610-eo-0004">mlns:w="http://www.wiley.com/namespaces/wiley" xmlns:cr="urn://wiley-online-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2610-eo-0026">m3">2-bromo-1-(5-methyl-1-m>pm>-tolyl-1m>Hm>-1,2,3-triazol-4-yl)ethanone href="#jhet2610-eo-0026" rel="references:#jhet2610-eo-0026"> respectively. The new products were tested for their antimicrobial activities using 96-well micro-plate assay, and compound href="#jhet2610-eo-0015" rel="references:#jhet2610-eo-0015"> showed excellent antibacterial activities compared with Vancomycine (reference drugs), while compounds href="#jhet2610-eo-0013" rel="references:#jhet2610-eo-0013"> and href="#jhet2610-eo-0024" rel="references:#jhet2610-eo-0024"> exhibited good results against yeast. The minimum inhibitory concentration (MIC) was determined, and compound href="#jhet2610-eo-0015" rel="references:#jhet2610-eo-0015"> showed the lowest MIC against Gram positive bacteria while compound href="#jhet2610-eo-0013" rel="references:#jhet2610-eo-0013"> showed the lowest MIC against yeast.