Design and Synthesis of Novel 6-(5-Methyl-1H-1,2,3-triazol-4-yl)-5-[(2-(thiazol-2-yl)hydrazono)methyl]imidazo[2,1-b]thiazoles as Antimicrobial Agents

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• 作者：Bakr F. Abdel-Wahab ; Rizk E. Khidre and Ghada E. A. Awad
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：489-494
• 全文大小：425K
• ISSN：1943-5193

文摘

Novel 6-(1,2,3-triazol-4-yl)-5-[(2-(thiazol-2-yl)hydrazono)methyl]imidazo[2,1-b]thiazoles , , and were prepared by reaction of thiosemicarbazone with either hydrazonoyl chloride , phenacylbromides or y.com/namespaces/wiley" xmlns:cr="urn://wiley-online-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2610-eo-0004">y.com/namespaces/wiley" xmlns:cr="urn://wiley-online-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2610-eo-0026">2-bromo-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)ethanone respectively. The new products were tested for their antimicrobial activities using 96-well micro-plate assay, and compound showed excellent antibacterial activities compared with Vancomycine (reference drugs), while compounds and exhibited good results against yeast. The minimum inhibitory concentration (MIC) was determined, and compound showed the lowest MIC against Gram positive bacteria while compound showed the lowest MIC against yeast.