Synthesis of 10-substituted 3,6-Diphenyl-9-aryl-3,4,6,7,9,10-hexahydro-acridine-1,8(2H,5H)-dione Derivatives and Biological Activities

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• 作者：Fang-Ming Wang ; Dan Bao ; Bing-Xiang Hu ; Ze-Yu Zhou ; Deng-Deng Huang ; Li-Zhuang Chen and Yuan-Yuan Dan
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：784-788
• 全文大小：272K
• ISSN：1943-5193

文摘

A series of novel 10-substituted 3,6-diphenyl-9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione derivatives were synthesized by condensation of compounds with amines, which the compounds were synthesized by 5-phenylcyclohexane-1,3-dione and aromatic aldehydes according to Knoevenagel, Michael, and cyclization reactions in the presence of a very small amount of l-proline as catalyzed at room temperature. The structures of all the synthesized compounds were characterized by IR, 1H NMR, and MS. In addition, the molecular structures of compound have been determined by single-crystal X-ray diffraction analysis.