Nitrogen-Doped Carbon Quantum Dot Stabilized Magnetic Iron Oxide Nanoprobe for Fluorescence, Magnetic Resonance, and Computed Tomography Triple-Modal In Vivo Bioimaging

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• 作者：Xiaoli Liu ; Hui Jiang ; Jing Ye ; Chunqiu Zhao ; Shengping Gao ; Changyu Wu ; Changhui Li ; Jincheng Li and Xuemei Wang
• 刊名：Advanced Functional Materials
• 出版年：2016
• 出版时间：December 20, 2016
• 年：2016
• 卷：26
• 期：47
• 页码：8694-8706
• 全文大小：3641K
• ISSN：1616-3028

文摘

Multimodal imaging, which combines complementary information of two or more imaging modalities, offers huge advantages. In this paper, the synthesis, characterization, and application of superparamagnetic nitrogen-doped carbon-iron oxide hybrid quantum dots (C-Fe₃O₄ QDs) is reported for triple-modal bioimaging through fluorescence/magnetic resonance/computed tomography (FL/MR/CT). Especially, C-Fe₃O₄ QDs are synthesized by using poly (γ-glutamic acid) as a precursor and stabilizer via a green and facile one-pot hydrothermal approach. The as-prepared C-Fe₃O₄ QDs exhibit excellent water dispersibility, wavelength-tunable FL property with high quantum yield of about 21.6%, good photostability, strong superparamagnetic property as well as favorable biocompatibility. Meanwhile, these C-Fe₃O₄ QDs also show a transverse relaxivity value (r ₂) of 154.10 mm ⁻¹ s⁻¹ for T₂-weighted MR imaging mode and an observable X-ray attenuation effect for CT imaging mode. Moreover, the in vivo bioimaging of tumor-bearing nude mice by combining FL, MR, and CT images further demonstrates that the as-prepared C-Fe₃O₄ QDs can be readily and efficiently used in FL/MR/CT triple-modal tumor imaging. Hence, the new and facile one-pot synthesis strategy for preparing multifunctional C-Fe₃O₄ QDs nanoprobes provides a convenient way for achieving an effective and versatile agent for tumorous bioimaging/or diagnostics.