Association of the HNF1A polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke

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• 作者：Yi-Jiang Zhou ; Rui-Xing Yin ; Shao-Cai Hong ; Qian Yang ; Xiao-Li Cao and Wu-Xian Chen
• 刊名：The Journal of Gene Medicine
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：19
• 期：1-2
• 全文大小：201K
• ISSN：1521-2254

文摘

Hepatocyte nuclear factor-1α gene (HNF1A) single nucleotide polymorphisms (SNPs) have been associated with serum lipid traits in several previous genome-wide association studies. However, little is known about such associations in the Chinese populations. The present study aimed to determine the association of the HNF1A rs1169288, rs2259820, rs2464196 and rs2650000 SNPs and serum lipid traits, the risk of coronary artery disease (CAD) and ischemic stroke (IS).