Silver salts and DBU cooperatively catalyzed domino reaction of propargylic alcohols with trifluoromethyl ketones: direct method to trifluoromethyl-substituted 5-alkylidene-1,3-dioxolane derivatives

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• 作者：Jingjing Wang ; Feng Li ; Huanping Xie ; Mengmeng Xu ; Xiaobo Zhao ; Lantao Liu and Wen-Xian Zhao
• 刊名：Applied Organometallic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 全文大小：427K
• ISSN：1099-0739

文摘

A general and efficient synthesis of trifluoromethyl-substituted 5-alkylidene-1,3-dioxolanes using AgNO₃ and DBU cooperatively catalyzed domino reaction of propargylic alcohols and trifluoromethyl ketones is described. The reaction tolerates a broad range of functional groups, and the desired products are obtained in good to excellent yields (62–99%) with acceptable diastereoselectivities. Copyright