Endothelin receptor blockers reduce shunting and angiogenesis in cirrhotic rats

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• 作者：Shao-Jung Hsu ; Te-Yueh Lin ; Sun-Sang Wang ; Chiao-Lin Chuang ; Fa-Yauh Lee ; Hui-Chun Huang ; I-Fang Hsin ; Jing-Yi Lee ; Han-Chieh Lin and Shou-Dong Lee
• 刊名：European Journal of Clinical Investigation
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：46
• 期：6
• 页码：572-580
• 全文大小：930K
• ISSN：1365-2362

文摘

Angiogenesis plays a pivotal role in splanchnic hyperaemia and portosystemic collateral formation in cirrhosis. Endothelin-1 (ET-1), an endothelium-derived vasoconstrictor, has also been implicated in the pathogenesis of cirrhosis and portal hypertension.