Rhodium-Catalyzed Asymmetric Hydrogenation of Tetrasubstituted Cyclic Enamides: Efficient Access to Chiral Cycloalkylamine Derivatives

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• 作者：Xiuxiu Li ; Cai You ; Hailong Yang ; Jinteng Che ; Pengyu Chen ; Yusheng Yang ; Hui Lv and Xumu Zhang
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2017
• 出版时间：February 20, 2017
• 年：2017
• 卷：359
• 期：4
• 页码：597-602
• 全文大小：1279K
• ISSN：1615-4169

文摘

An efficient rhodium-catalyzed asymmetric hydrogenation of challenging tetrasubstituted cyclic enamides has been developed, affording cyclic chiral amides with high yields and excellent enantioselectivities (up to 99% yield and >99% ee). This novel methodology provides an efficient and concise synthetic route to chiral cycloalkylamines with two contiguous stereogenic centers. The potential utility of this protocol in the synthesis of bioactive molecules is also disclosed.