Recent Advances in Multicomponent Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles

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• 作者：Zhengkai Chen ; Zhubo Liu ; Gangjian Cao ; Hongli Li and Hongjun Ren
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2017
• 出版时间：January 19, 2017
• 年：2017
• 卷：359
• 期：2
• 页码：202-224
• 全文大小：5848K
• ISSN：1615-4169

文摘

1,4,5-Trisubstituted 1,2,3-triazoles have been regarded as highly significant nitrogen-containing heterocycles due to their broad spectrum of biological activities and other prominent properties. Well-established pioneering examples indicate that multicomponent reactions (MCRs) are a straightforward and powerful tool for the construction of various functionalized heterocyclic molecules, especially fully-decorated 1,2,3-triazoles. The recent progress regarding synthetic approaches towards differently substituted types of 1,2,3-triazoles via MCRs and the relevant mechanistic investigations is summarized in this review.