An Iron(II) Chloride-Promoted Radical Cascade Methylation or α-Chloro-β-methylation of N-Arylacrylamides with Dimethyl Sulfoxide

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• 作者：Zejiang Li ; Xiaosong Cui ; Lin Niu ; Yingming Ren ; Menghua Bian ; Xuebiao Yang ; Biao Yang ; Qinqin Yan and Jincan Zhao
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2017
• 出版时间：January 19, 2017
• 年：2017
• 卷：359
• 期：2
• 页码：246-249
• 全文大小：866K
• ISSN：1615-4169

文摘

A free radical-initiated methylation and/or α-chloro-β-methylation of N-arylacrylamides with dimethyl sulfoxide under the analogous Fenton reaction condition has been developed, which provides an effective and facile cascade strategy for the synthesis of oxindoles and chlorinated amides.