ChemInform Abstract: Stereoselective Formation of Chiral trans-4-Hydroxy-5-substituted 2-pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A.
A novel one-pot method for the diastereoselective synthesis of trans-4-hydroxy-5-substituted 2-pyrrolidinones via intramolecular cascade reaction of a series of Grignard reagents is presented.