Pharmacokinetics of ixazomib, an oral proteasome inhibitor, in solid tumour patients with moderate or severe hepatic impairment

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• 作者：Neeraj Gupta ; Michael J. Hanley ; Karthik Venkatakrishnan ; Raymond Perez ; Robin E. Norris ; John Nemunaitis ; Huyuan Yang ; Mark G. Qian ; Gerald Falchook ; Richard Labotka and Siqing Fu
• 刊名：British Journal of Clinical Pharmacology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：82
• 期：3
• 页码：728-738
• 全文大小：670K
• ISSN：1365-2125

文摘

The aim of the present study was to characterize the pharmacokinetics of the oral proteasome inhibitor, ixazomib, in patients with solid tumours and moderate or severe hepatic impairment, to provide posology recommendations.