Declined hTERT expression of peripheral blood CD4+ T cells in oral lichen planus correlated with clinical parameter

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• 作者：Jing Zhang ; Ming-hui Wei ; Rui Lu ; Ge-fei Du and Gang Zhou
• 刊名：Journal of Oral Pathology & Medicine
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：45
• 期：7
• 页码：516-522
• 全文大小：186K
• ISSN：1600-0714

文摘

Oral lichen planus (OLP) is a chronic, T-cell-mediated inflammatory autoimmune disease. Human telomerase reverse transcriptase (hTERT), a catalytic subunit bearing the enzymatic activity of telomerase, may have a unique function in regulating the activation, proliferation, and function of T lymphocytes. The goal of this study was to investigate the expression of hTERT in CD4⁺ and CD8⁺ T cells from patients with OLP and its correlation with clinical parameter.