Global DNA hypomethylation is associated with the development and poor prognosis of tongue squamous cell carcinoma

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• 作者：Hung-Chih Chen ; Cheng-Mei Yang ; Jiin-Tsuey Cheng ; Kuo-Wang Tsai ; Ting-Ying Fu ; Huei-Han Liou ; Hui-Hwa Tseng ; Jang-Hwa Lee ; Guan-Cheng Li ; Jyh-Seng Wang ; Yu-Yi Hou ; Ta-Jung Weng and Luo-Ping Ger
• 刊名：Journal of Oral Pathology & Medicine
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：45
• 期：6
• 页码：409-417
• 全文大小：295K
• ISSN：1600-0714

文摘

Oral cancer is the 4th leading cause of cancer death for males and the top cancer in young adult males in Taiwan. Tongue squamous cell carcinoma (TSCC) is a common oral cancer and generally associated with poor prognosis. Global DNA hypomethylation at the 5 position of cytosine (5mC) is a well-known epigenetic feature of cancer. Therefore, the purpose of this study was to investigate the relationship of the global 5mC content with the tumorigenesis and prognosis of patients with TSCC.