As2O3 combined with leflunomide prolongs heart xenograft survival via suppressing the response of Th1, Th2, and B cells in a rat model

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• 作者：Zhi-Xing Jiao ; Yun Leng ; Jun-Jie Xia ; Hai-Qiao Wu ; Ning Jin ; Jia-Zhao Fu ; Lian-Na Cheng ; Jin-Hua Wang ; Shao-Bin Ni and Zhong-Quan Qi
• 刊名：Xenotransplantation
• 出版年：2016
• 出版时间：May/June 2016
• 年：2016
• 卷：23
• 期：3
• 页码：237-248
• 全文大小：3315K
• ISSN：1399-3089

文摘

Xenotransplantation remits the severe shortage of human organs and tissues for transplantation, which is a problem that severely limits the application of transplantation to the treatment of human disease. However, severe immune rejection significantly limits the efficacy of xenotransplantation. In this study, we systematically investigated the immunosuppressive effect and mechanism of action of As₂O₃ and leflunomide using a hamster-to-rat heart xenotransplantation model. We initially examined heart xenograft survival following As₂O₃ and leflunomide treatment alone or combined treatment. We found that treatment with As₂O₃ combined with leflunomide can significantly prolong the survival of heart xenograft by inhibiting Th1 and Th2 differentiation and reducing the production of IgG and IgM. Interestingly, As₂O₃ and leflunomide showed low toxicity to the organs of the recipient. Taken together, these observations indicate that treatment with As₂O₃ combined with leflunomide may be a promising immunosuppressive schedule for xenotransplantation.