Biomimetic Transmembrane Channels with High Stability and Transporting Efficiency from Helically Folded Macromolecules

详细信息    查看全文

• 作者：Dr. Chao Lang ; Dr. Wenfang Li ; Prof. Zeyuan Dong ; Dr. Xin Zhang ; Feihu Yang ; Prof. Bing Yang ; Xiaoli Deng ; Chenyang Zhang ; Jiayun Xu and Prof. Junqiu Liu
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：August 8, 2016
• 年：2016
• 卷：128
• 期：33
• 页码：9875-9879
• 全文大小：1384K
• ISSN：1521-3757

文摘

Membrane channels span the cellular lipid bilayers to transport ions and molecules into cells with sophisticated properties including high efficiency and selectivity. It is of particular biological importance in developing biomimetic transmembrane channels with unique functions by means of chemically synthetic strategies. An artificial unimolecular transmembrane channel using pore-containing helical macromolecules is reported. The self-folding, shape-persistent, pore-containing helical macromolecules are able to span the lipid bilayer, and thus result in extraordinary channel stability and high transporting efficiency for protons and cations. The lifetime of this artificial unimolecular channel in the lipid bilayer membrane is impressively long, rivaling those of natural protein channels. Natural channel mimics designed by helically folded polymeric scaffolds will display robust and versatile transport-related properties at single-molecule level.