Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species

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• 作者：Yajie Zhang ; Fengping Chen ; Jiading Chen ; Suqun Huang ; Junbin Chen ; Jian Huang ; Nan Li ; Suxia Sun ; Xinwei Chu and Longying Zha
• 刊名：Molecular Nutrition & Food Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：60
• 期：7
• 页码：1532-1543
• 全文大小：3576K
• ISSN：1613-4133

文摘

We and others recently showed that soyasaponin Bb (SS_Bb) inhibited lipopolysaccharide (LPS)-induced inflammation in macrophages. Since the recruitment of toll-like receptor 4 (TLR4) into lipid rafts is vital for LPS-initiated signaling, we investigated whether this process would be modulated by SS_Bb.