Adding genetic risk score to family history identifies twice as many high-risk men for prostate cancer: Results from the prostate cancer prevention trial

详细信息    查看全文

• 作者：Haitao Chen ; Xu Liu ; Charles B. Brendler ; Donna P. Ankerst ; Robin J. Leach ; Phyllis J. Goodman ; M. Scott Lucia ; Catherine M. Tangen ; Li Wang ; Fang-Chi Hsu ; Jielin Sun ; A. Karim Kader ; William B. Isaacs ; Brian T. Helfand ; S.Lilly Zheng ; Ian M. Thompson ; Elizabeth A. Platz and Jianfeng Xu
• 刊名：The Prostate
• 出版年：2016
• 出版时间：September 1, 2016
• 年：2016
• 卷：76
• 期：12
• 页码：1120-1129
• 全文大小：653K
• ISSN：1097-0045

文摘

While family history (FH) has been widely used to provide risk information, it captures only a small proportion of subjects with higher genetic susceptibility. Our objective is to assess whether a genetic risk score (GRS) calculated from prostate cancer (PCa) risk-associated single nucleotide polymorphisms (SNPs) can supplement FH for more effective risk stratification for PCa screening decision-making.