White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

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• 作者：Seonjoo Lee ; Fawad Viqar ; Molly E. Zimmerman ; Atul Narkhede ; Giuseppe Tosto ; Tammie L.S. Benzinger ; Daniel S. Marcus ; Anne M. Fagan ; Alison Goate ; Nick C. Fox ; Nigel J. Cairns ; David M. Holtzman ; Virginia Buckles ; Bernardino Ghetti ; Eric McDade ; Ralph N. Martins ; Andrew J. Saykin ; Colin L. Masters ; John M. Ringman ; Natalie S. Ryan ; Stefan Fö ; rster ; Christoph Laske ; Peter R. Schofield ; Reisa A. Sperling ; Stephen Salloway ; Stephen Correia ; Clifford Jack Jr. ; Michael Weiner ; Randall J. Bateman ; John C. Morris ; Richard Mayeux ; Adam M. Brickman and for the Dominantly Inherited Alzheimer Network
• 刊名：Annals of Neurology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：79
• 期：6
• 页码：929-939
• 全文大小：441K
• ISSN：1531-8249

文摘

White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression of Alzheimer's disease (AD). These observations are typically interpreted as evidence that vascular abnormalities play an additive, independent role contributing to symptom presentation, but not core features of AD. We examined the severity and distribution of WMH in presymptomatic PSEN1, PSEN2, and APP mutation carriers to determine the extent to which WMH manifest in individuals genetically determined to develop AD.