Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand 胰岛素通过肿瘤坏死因子相关凋亡诱导配体的差异调节来促进血管平滑肌细胞的增殖与凋亡

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• 作者：Hanis H. Harith ; Belinda A. Di Bartolo ; Siâ ; n P. Cartland ; Scott Genner and Mary M. Kavurma
• 刊名：Journal of Diabetes
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：8
• 期：4
• 页码：568-578
• 全文大小：511K
• ISSN：1753-0407

文摘

Insulin regulates glucose homeostasis but can also promote vascular smooth muscle (VSMC) proliferation, important in atherogenesis. Recently, we showed that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) stimulates intimal thickening via accelerated growth of VSMCs. The aim of the present study was to determine whether insulin-induced effects on VSMCs occur via TRAIL.