Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors combined with chemotherapy in first-line treatment in an advanced non-small cell lung cancer patient with EGFR sensitive mutation

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• 作者：Aimi Huang ; Rong Li ; Jikai Zhao ; Xiaofei Wang ; Bo Jin ; Yanjie Niu ; Jie Zhang ; Liyan Jiang and Baohui Han
• 刊名：Thoracic Cancer
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：7
• 期：5
• 页码：614-618
• 全文大小：1297K
• ISSN：1759-7714

文摘

This article demonstrates a case of a lung adenocarcinoma patient in stage IV harboring an epidermal growth factor receptor (EGFR) 19 exon deletion mutation treated with 500 mg/m² pemetrexed and 75 mg/m² cisplatin on day 1, sequenced with 250 mg gefitinib on prescription on days 4–28 for six cycles as first-line, then by gefitinib combined with pemetrexed as maintenance therapy. The patient achieved a partial response. Performance status increased from grade 2 to 1. The progression-free survival period was 17 months. Overall survival is now over three years. Side effects of grade two liver dysfunction and dermal toxicity were tolerable. Combined gefitinib with platinum-based chemotherapy as first-line treatment probably benefits non-small cell cancer patients in stage IV harboring sensitive EGFR gene mutations with a better local control rate, longer survival, and tolerable side effects.