Oxidative Remote C−H Trifluoromethylation of Quinolineamides on the C5 Position with Iodobenzene Diacetate as the Oxidizing Agent

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• 作者：Zhaoyang Wu ; Yongqin He ; Chaowei Ma ; Xiaoqiang Zhou ; Xingxing Liu ; Yamin Li ; Ting Hu ; Dr. Ping Wen and Prof. Dr. Guosheng Huang
• 刊名：Asian Journal of Organic Chemistry
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：5
• 期：6
• 页码：724-728
• 全文大小：447K
• ISSN：2193-5815

文摘

A facile, metal-free protocol has been developed for the remote trifluoromethylation of 8-aminoquinoline scaffolds on the C5 position, which is difficult to functionalize. In this method, 8-aminoquinolineamides reacted with an inexpensive and commercially available CF₃ source (Langlois reagent) to give a wide range of trifluoromethylated aminoquinolineamides.