Capture-based next-generation sequencing reveals multiple actionable mutations in cancer patients failed in traditional testing

详细信息    查看全文

• 作者：Jing Xie ; Xiongxiong Lu ; Xue Wu ; Xiaoyi Lin ; Chao Zhang ; Xiaofang Huang ; Zhili Chang ; Xinjing Wang ; Chenlei Wen ; Xiaomei Tang ; Minmin Shi ; Qian Zhan ; Hao Chen ; Xiaxing Deng ; Chenghong Peng ; Hongwei Li ; Yuan Fang ; Yang Shao and Baiyong Shen
• 刊名：Molecular Genetics & Genomic Medicine
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：4
• 期：3
• 页码：262-272
• 全文大小：1595K
• ISSN：2324-9269

文摘

Targeted therapies including monoclonal antibodies and small molecule inhibitors have dramatically changed the treatment of cancer over past 10 years. Their therapeutic advantages are more tumor specific and with less side effects. For precisely tailoring available targeted therapies to each individual or a subset of cancer patients, next-generation sequencing (NGS) has been utilized as a promising diagnosis tool with its advantages of accuracy, sensitivity, and high throughput.