Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

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• 作者：Qian Chen ; Liangzhu Feng ; Jingjing Liu ; Wenwen Zhu ; Ziliang Dong ; Yifan Wu and Zhuang Liu
• 刊名：Advanced Materials
• 出版年：2016
• 出版时间：September 7, 2016
• 年：2016
• 卷：28
• 期：33
• 页码：7129-7136
• 全文大小：2479K
• ISSN：1521-4095

文摘

A unique type of pH/H₂O₂ dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO₂ is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.