Rh-Catalyzed Direct Amination of Unactivated C(sp3)−H bond with Anthranils Under Mild Conditions

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• 作者：Conghui Tang ; Miancheng Zou ; Jianzhong Liu ; Xiaojin Wen ; Xiang Sun ; Yiqun Zhang and Prof. Ning Jiao
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：August 1, 2016
• 年：2016
• 卷：22
• 期：32
• 页码：11165-11169
• 全文大小：1551K
• ISSN：1521-3765

文摘

C−N Bond formation is of great significance due to the ubiquity of nitrogen-containing compounds. Here, a mild and efficient Rh^III-catalyzed C(sp³)−H aryl amination reaction is reported. Anthranil is employed as the nitrogen source with 100 % atom efficiency. This C−H amination reaction exhibits broad substrate scope without using any external oxidants. Mechanistic studies including rhodacycle intermediates, H–D exchange, kinetic isotope effect (KIE) experiments, and in situ IR are presented.