Zn or O? An Atomic Level Comparison on Antibacterial Activities of Zinc Oxides

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• 作者：Fen Yu ; Dr. Xuan Fang ; Huimin Jia ; Miaoxing Liu ; Xiaotong Shi ; Chaowen Xue ; Dr. Tingtao Chen ; Prof. Zhipeng Wei ; Prof. Fang Fang ; Prof. Hui Zhu ; Prof. Hongbo Xin ; Prof. Jing Feng and Prof. Xiaolei Wang
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：June 6, 2016
• 年：2016
• 卷：22
• 期：24
• 页码：8053-8058
• 全文大小：1217K
• ISSN：1521-3765

文摘

For the first time, the influence of different types of atoms (Zn and O) on the antibacterial activities of nanosized ZnO was quantitatively evaluated with the aid of a 3D-printing-manufactured evaluation system. Two different outermost atomic layers were manufactured separately by using an ALD (atomic layer deposition) method. Interestingly, we found that each outermost atomic layer exhibited certain differences against gram-positive or gram-negative bacterial species. Zinc atoms as outermost layer (ZnO−Zn) showed a more pronounced antibacterial effect towards gram-negative E. coli (Escherichia coli), whereas oxygen atoms (ZnO−O) showed a stronger antibacterial activity against gram-positive S. aureus (Staphylococcus aureus). A possible antibacterial mechanism has been comprehensively discussed from different perspectives, including Zn²⁺ concentrations, oxygen vacancies, photocatalytic activities and the DNA structural characteristics of different bacterial species.